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Similar to p53,FoxO controls both pro-survival and pro-apoptotic processes via activation of dif-ferent sets of genes involved in regulation of cell death and cell cycle arrest as wellas metabolism and ROS [36]. The formerare useful in tracer studies, because they traversethe tissues and can be monitored by a counter,while the latter are utilized for their destructiveeffect on thyroid cells.

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The typical approach to animal chemicalteratogenicity assessment is shown in Figure 13.1.

Love IM, Grossman SR (2012) It takes 15 to tango: making sense of the many ubiquitinligases of p53. Serchov T, Dubois-Pot-Schneider H, Charlot C, Rosl F, Wasylyk B (2010) Involvement of netand Hif1? in distinct yet intricately linked hypoxia-induced signaling pathways. These cuboidal cellsare interspersed among the type I cells but tend to con-gregate at septal junctions. This pressure created suchpolitical anxiety in the mid-1990s that in the short term Britain ministers opted to slow asylumrun-down and keep high investment levels in beds. It causes neurological paralysisin insects, probably by delaying depolarization.Toxicity of permethrin in humans is very low;apparently 40–400 times lower than that oflindane

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